In Situ Detection of Chromogranin A Released from Living Neurons with a Single-Walled Carbon-Nanotube Field-Effect Transistor

Transistors tune in: The chromogranin A (CgA) released from the synaptic terminal of cortical neurons can be detected in situ by immobilization of an antibody against CgA on a single‐walled carbon‐nanotube field‐effect transistor (see picture), to give a device with high selectivity, sensitivity, an...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2007-08, Vol.3 (8), p.1350-1355
Hauptverfasser:	Wang, Chen-Wei, Pan, Chien-Yuan, Wu, Hsing-Chen, Shih, Po-Yuan, Tsai, Chia-Chang, Liao, Kuo-Tang, Lu, Li-Long, Hsieh, Wen-Hsing, Chen, Chii-Dong, Chen, Yit-Tsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods biosensors carbon nanotubes Cells, Cultured Cerebral Cortex - metabolism Chromogranin A - metabolism Equipment Design Equipment Failure Analysis field-effect transistors Microelectrodes Nanotechnology - instrumentation Nanotechnology - methods Nanotubes, Carbon - chemistry Nanotubes, Carbon - ultrastructure neurons Neurons - metabolism Particle Size Rats Rats, Sprague-Dawley Synaptic Transmission - physiology Transistors, Electronic
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Zusammenfassung:	Transistors tune in: The chromogranin A (CgA) released from the synaptic terminal of cortical neurons can be detected in situ by immobilization of an antibody against CgA on a single‐walled carbon‐nanotube field‐effect transistor (see picture), to give a device with high selectivity, sensitivity, and real‐time detection capability. This biosensory technique can be used to study the activity of individual living neurons.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200600723