Double-Stranded RNA Polyinosinic-Polycytidylic Acid Immobilized onto γ-Fe2O3 Nanoparticles by Using a Multifunctional Polymeric Linker

Magnetic medicines: The immobilization of the abnormal nucleic acid polyinosinic–polycytidylic acid (poly(IC)) on γ‐Fe2O3 maghemite nanoparticles through the phosphoramidate route by using a multifunctional polymer is reported. This approach may open new possibilities for magnetic drug delivery appl...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2007-08, Vol.3 (8), p.1374-1378
Hauptverfasser:	Shukoor, Mohammed Ibrahim, Natalio, Filipe, Ksenofontov, Vadim, Tahir, Muhammad Nawaz, Eberhardt, Marc, Theato, Patrick, Schröder, Heinz C., Müller, Werner E. G., Tremel, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Coated Materials, Biocompatible - chemistry Crystallization - methods Ferric Compounds - chemistry immobilization Immunomagnetic Separation - methods iron Macromolecular Substances - chemistry magnetic materials Materials Testing Molecular Conformation nanoparticles Nanostructures - chemistry Nanostructures - ultrastructure Nanotechnology - methods Particle Size Poly I-C - chemistry Polymers - chemistry RNA RNA, Double-Stranded - chemistry RNA, Double-Stranded - ultrastructure Surface Properties
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Zusammenfassung:	Magnetic medicines: The immobilization of the abnormal nucleic acid polyinosinic–polycytidylic acid (poly(IC)) on γ‐Fe2O3 maghemite nanoparticles through the phosphoramidate route by using a multifunctional polymer is reported. This approach may open new possibilities for magnetic drug delivery applications. The image shows γ‐Fe2O3 nanoparticles after polymer functionalization.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200600664