Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea
The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of Baptisia tinctoria and Echinacea pallida and...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2006-11, Vol.13 (9), p.688-694 |
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| creator | Classen, B. Thude, S. Blaschek, W. Wack, M. Bodinet, C. |
| description | The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of
Baptisia tinctoria and
Echinacea pallida and suspension culture of
Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of
B. tinctoria and
E. pallida show high activity in all test systems. AGP from cell culture of
E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture. |
| doi_str_mv | 10.1016/j.phymed.2005.10.004 |
| format | Article |
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Baptisia tinctoria and
Echinacea pallida and suspension culture of
Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of
B. tinctoria and
E. pallida show high activity in all test systems. AGP from cell culture of
E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2005.10.004</identifier><identifier>PMID: 17085292</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Arabinogalactan-protein ; Baptisia tinctoria ; Beans ; Cell Proliferation - drug effects ; Cells, Cultured ; Echinacea ; Echinacea - chemistry ; Echinacea pallida ; Echinacea purpurea ; Fabaceae - chemistry ; Health aspects ; Immunoglobulin M - metabolism ; Immunological adjuvants ; Immunomodulatory effect ; Immunopharmacology ; Interleukin-6 - metabolism ; Legumes ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Macrophages, Alveolar - drug effects ; Macrophages, Alveolar - metabolism ; Medicinal plants ; Mice ; Mimosaceae ; Mucoproteins - isolation & purification ; Mucoproteins - pharmacology ; Nitrites - metabolism ; Plant Proteins - isolation & purification ; Plant Proteins - pharmacology ; Plant Roots - chemistry</subject><ispartof>Phytomedicine (Stuttgart), 2006-11, Vol.13 (9), p.688-694</ispartof><rights>2005 Elsevier GmbH</rights><rights>COPYRIGHT 2006 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-26e394ba48223cb72e0ff0c53ceeb025fcd4dfde3832b440a430b940febb36f43</citedby><cites>FETCH-LOGICAL-c531t-26e394ba48223cb72e0ff0c53ceeb025fcd4dfde3832b440a430b940febb36f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2005.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17085292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Classen, B.</creatorcontrib><creatorcontrib>Thude, S.</creatorcontrib><creatorcontrib>Blaschek, W.</creatorcontrib><creatorcontrib>Wack, M.</creatorcontrib><creatorcontrib>Bodinet, C.</creatorcontrib><title>Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of
Baptisia tinctoria and
Echinacea pallida and suspension culture of
Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of
B. tinctoria and
E. pallida show high activity in all test systems. AGP from cell culture of
E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture.</description><subject>Animals</subject><subject>Arabinogalactan-protein</subject><subject>Baptisia tinctoria</subject><subject>Beans</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Echinacea</subject><subject>Echinacea - chemistry</subject><subject>Echinacea pallida</subject><subject>Echinacea purpurea</subject><subject>Fabaceae - chemistry</subject><subject>Health aspects</subject><subject>Immunoglobulin M - metabolism</subject><subject>Immunological adjuvants</subject><subject>Immunomodulatory effect</subject><subject>Immunopharmacology</subject><subject>Interleukin-6 - metabolism</subject><subject>Legumes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Macrophages, Alveolar - drug effects</subject><subject>Macrophages, Alveolar - metabolism</subject><subject>Medicinal plants</subject><subject>Mice</subject><subject>Mimosaceae</subject><subject>Mucoproteins - isolation & purification</subject><subject>Mucoproteins - pharmacology</subject><subject>Nitrites - metabolism</subject><subject>Plant Proteins - isolation & purification</subject><subject>Plant Proteins - pharmacology</subject><subject>Plant Roots - chemistry</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rj6D0QKgnetJ03SjxthXdZ1YUEvFLwLaXKym6FNxqQV5t-b0kFYGCQXgXOeN8nJQ8hbChUF2nzcV4fH44SmqgFELlUA_BnZ0YZ2JfTi13Oyg57zsqWUXZBXKe0BKO9beEkuaAudqPt6R77fTdPiwxTMMqo5xGOB1qKeUxFsoaIanA8PalR6Vr48xDCj86mwMUzFZ3WYXXKqUN4UN_rReaVRvSYvrBoTvjntl-Tnl5sf11_L-2-3d9dX96UWjM5l3SDr-aB4V9dMD22NYC3knkYcoBZWG26sQdaxeuAcFGcw9BwsDgNrLGeX5MN2bn7U7wXTLCeXNI6j8hiWJJuOUiEakcH3G5jHQOm8DXNUeoXlFRVtyxvesEyVZ6gH9BjVGDxal8tP-OoMn5fByemzAb4FdAwpRbTyEN2k4lFSkKtQuZebULkKXatZaI69O425DGvvX-hkMAOfNgDzZ_9xGGXSDr1G42L2KE1w_7_hLzUmsv8</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Classen, B.</creator><creator>Thude, S.</creator><creator>Blaschek, W.</creator><creator>Wack, M.</creator><creator>Bodinet, C.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea</title><author>Classen, B. ; Thude, S. ; Blaschek, W. ; Wack, M. ; Bodinet, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-26e394ba48223cb72e0ff0c53ceeb025fcd4dfde3832b440a430b940febb36f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arabinogalactan-protein</topic><topic>Baptisia tinctoria</topic><topic>Beans</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Echinacea</topic><topic>Echinacea - chemistry</topic><topic>Echinacea pallida</topic><topic>Echinacea purpurea</topic><topic>Fabaceae - chemistry</topic><topic>Health aspects</topic><topic>Immunoglobulin M - metabolism</topic><topic>Immunological adjuvants</topic><topic>Immunomodulatory effect</topic><topic>Immunopharmacology</topic><topic>Interleukin-6 - metabolism</topic><topic>Legumes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>Macrophages, Alveolar - drug effects</topic><topic>Macrophages, Alveolar - metabolism</topic><topic>Medicinal plants</topic><topic>Mice</topic><topic>Mimosaceae</topic><topic>Mucoproteins - isolation & purification</topic><topic>Mucoproteins - pharmacology</topic><topic>Nitrites - metabolism</topic><topic>Plant Proteins - isolation & purification</topic><topic>Plant Proteins - pharmacology</topic><topic>Plant Roots - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Classen, B.</creatorcontrib><creatorcontrib>Thude, S.</creatorcontrib><creatorcontrib>Blaschek, W.</creatorcontrib><creatorcontrib>Wack, M.</creatorcontrib><creatorcontrib>Bodinet, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Classen, B.</au><au>Thude, S.</au><au>Blaschek, W.</au><au>Wack, M.</au><au>Bodinet, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>13</volume><issue>9</issue><spage>688</spage><epage>694</epage><pages>688-694</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of
Baptisia tinctoria and
Echinacea pallida and suspension culture of
Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of
B. tinctoria and
E. pallida show high activity in all test systems. AGP from cell culture of
E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>17085292</pmid><doi>10.1016/j.phymed.2005.10.004</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arabinogalactan-protein Baptisia tinctoria Beans Cell Proliferation - drug effects Cells, Cultured Echinacea Echinacea - chemistry Echinacea pallida Echinacea purpurea Fabaceae - chemistry Health aspects Immunoglobulin M - metabolism Immunological adjuvants Immunomodulatory effect Immunopharmacology Interleukin-6 - metabolism Legumes Lymphocytes - drug effects Lymphocytes - metabolism Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Medicinal plants Mice Mimosaceae Mucoproteins - isolation & purification Mucoproteins - pharmacology Nitrites - metabolism Plant Proteins - isolation & purification Plant Proteins - pharmacology Plant Roots - chemistry |
| title | Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea |
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