Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea

The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of Baptisia tinctoria and Echinacea pallida and...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2006-11, Vol.13 (9), p.688-694
Hauptverfasser:	Classen, B., Thude, S., Blaschek, W., Wack, M., Bodinet, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabinogalactan-protein Baptisia tinctoria Beans Cell Proliferation - drug effects Cells, Cultured Echinacea Echinacea - chemistry Echinacea pallida Echinacea purpurea Fabaceae - chemistry Health aspects Immunoglobulin M - metabolism Immunological adjuvants Immunomodulatory effect Immunopharmacology Interleukin-6 - metabolism Legumes Lymphocytes - drug effects Lymphocytes - metabolism Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Medicinal plants Mice Mimosaceae Mucoproteins - isolation & purification Mucoproteins - pharmacology Nitrites - metabolism Plant Proteins - isolation & purification Plant Proteins - pharmacology Plant Roots - chemistry
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Zusammenfassung:	The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of Baptisia tinctoria and Echinacea pallida and suspension culture of Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of B. tinctoria and E. pallida show high activity in all test systems. AGP from cell culture of E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture.
ISSN:	0944-7113 1618-095X
DOI:	10.1016/j.phymed.2005.10.004