Rapid systemic uptake of allergens through the respiratory mucosa

Rapid systemic uptake of allergens through the respiratory mucosa

In OVA-sensitized mice OVA could not be used for the absorption study because of interference of OVA-specific antibodies of the allergic mice with the ELISA. [...]horseradish peroxidase (HRP; Sigma), which has a molecular weight (40 kd) that is comparable with that of OVA (45 kd), was administered a...

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Veröffentlicht in:Journal of allergy and clinical immunology 2007-08, Vol.120 (2), p.472-474
Hauptverfasser: Hens, Greet, MD, Bobic, Sonja, MSc, Reekmans, Kristien, MSc, Ceuppens, Jan Louis, MD, PhD, Hellings, Peter Wim, MD, PhD
Format: Artikel
Sprache:eng
Schlagworte:
Absorption
Allergens - immunology
Allergens - pharmacokinetics
Allergies
Allergy and Immunology
Animals
Bronchi - metabolism
Experiments
Inflammation - immunology
Male
Mice
Mice, Inbred BALB C
Molecular weight
Nasal Cavity - metabolism
Ovalbumin - immunology
Ovalbumin - pharmacokinetics
Respiratory Mucosa - metabolism
Time Factors
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Zusammenfassung:In OVA-sensitized mice OVA could not be used for the absorption study because of interference of OVA-specific antibodies of the allergic mice with the ELISA. [...]horseradish peroxidase (HRP; Sigma), which has a molecular weight (40 kd) that is comparable with that of OVA (45 kd), was administered at the same dose as OVA in prior experiments.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.03.047