Phenotypic analysis of a novel chordin mutant in medaka
We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over‐bifurcation of yolk sac blood vessels, and late...
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| Veröffentlicht in: | Developmental dynamics 2007-08, Vol.236 (8), p.2298-2310 |
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| creator | Takashima, Shigeo Shimada, Atsuko Kobayashi, Daisuke Yokoi, Hayato Narita, Takanori Jindo, Tomoko Kage, Takahiro Kitagawa, Tadao Kimura, Tetsuaki Sekimizu, Koshin Miyake, Akimitsu Setiamarga, Davin H.E. Murakami, Ryohei Tsuda, Sachiko Ooki, Shinya Kakihara, Ken Hojo, Motoki Naruse, Kiyoshi Mitani, Hiroshi Shima, Akihiro Ishikawa, Yuji Araki, Kazuo Saga, Yumiko Takeda, Hiroyuki |
| description | We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over‐bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits variability of phenotypes, depending on the culture temperature, from embryos with a slightly ventralized phenotype to those without any head and trunk structures. Taking advantages of these variable and severe phenotypes, we analyzed the role of Chordin‐dependent tissues such as the notochord and Kupffer's vesicle (KV) in the establishment of left–right axis in fish. The results demonstrate that, in the absence of the notochord and KV, the medaka lateral plate mesoderm autonomously and bilaterally expresses spaw gene in a default state. Developmental Dynamics 236:2298–2310, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.21245 |
| format | Article |
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The mutant exhibits ventralization of the body axis, malformation of axial bones, over‐bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits variability of phenotypes, depending on the culture temperature, from embryos with a slightly ventralized phenotype to those without any head and trunk structures. Taking advantages of these variable and severe phenotypes, we analyzed the role of Chordin‐dependent tissues such as the notochord and Kupffer's vesicle (KV) in the establishment of left–right axis in fish. The results demonstrate that, in the absence of the notochord and KV, the medaka lateral plate mesoderm autonomously and bilaterally expresses spaw gene in a default state. Developmental Dynamics 236:2298–2310, 2007. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.21245</identifier><identifier>PMID: 17654721</identifier><language>eng</language><publisher>New York: Wiley‐Liss, Inc</publisher><subject>Animals ; BMP ; Body Patterning - genetics ; Cells, Cultured ; chordin ; dorsal‐ventral patterning ; Embryo, Nonmammalian ; Freshwater ; Glycoproteins - genetics ; Intercellular Signaling Peptides and Proteins - genetics ; Kupffer's vesicle ; medaka ; Mutation ; Notochord ; Oryzias - embryology ; Oryzias - genetics ; Oryzias latipes ; Phenotype ; Temperature</subject><ispartof>Developmental dynamics, 2007-08, Vol.236 (8), p.2298-2310</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><rights>(c) 2007 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5995-f9c1544dcf883632fe278afbec8fee89a0570c8580a817cb8ca1733a661e78d03</citedby><cites>FETCH-LOGICAL-c5995-f9c1544dcf883632fe278afbec8fee89a0570c8580a817cb8ca1733a661e78d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.21245$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.21245$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17654721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takashima, Shigeo</creatorcontrib><creatorcontrib>Shimada, Atsuko</creatorcontrib><creatorcontrib>Kobayashi, Daisuke</creatorcontrib><creatorcontrib>Yokoi, Hayato</creatorcontrib><creatorcontrib>Narita, Takanori</creatorcontrib><creatorcontrib>Jindo, Tomoko</creatorcontrib><creatorcontrib>Kage, Takahiro</creatorcontrib><creatorcontrib>Kitagawa, Tadao</creatorcontrib><creatorcontrib>Kimura, Tetsuaki</creatorcontrib><creatorcontrib>Sekimizu, Koshin</creatorcontrib><creatorcontrib>Miyake, Akimitsu</creatorcontrib><creatorcontrib>Setiamarga, Davin H.E.</creatorcontrib><creatorcontrib>Murakami, Ryohei</creatorcontrib><creatorcontrib>Tsuda, Sachiko</creatorcontrib><creatorcontrib>Ooki, Shinya</creatorcontrib><creatorcontrib>Kakihara, Ken</creatorcontrib><creatorcontrib>Hojo, Motoki</creatorcontrib><creatorcontrib>Naruse, Kiyoshi</creatorcontrib><creatorcontrib>Mitani, Hiroshi</creatorcontrib><creatorcontrib>Shima, Akihiro</creatorcontrib><creatorcontrib>Ishikawa, Yuji</creatorcontrib><creatorcontrib>Araki, Kazuo</creatorcontrib><creatorcontrib>Saga, Yumiko</creatorcontrib><creatorcontrib>Takeda, Hiroyuki</creatorcontrib><title>Phenotypic analysis of a novel chordin mutant in medaka</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over‐bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits variability of phenotypes, depending on the culture temperature, from embryos with a slightly ventralized phenotype to those without any head and trunk structures. Taking advantages of these variable and severe phenotypes, we analyzed the role of Chordin‐dependent tissues such as the notochord and Kupffer's vesicle (KV) in the establishment of left–right axis in fish. The results demonstrate that, in the absence of the notochord and KV, the medaka lateral plate mesoderm autonomously and bilaterally expresses spaw gene in a default state. Developmental Dynamics 236:2298–2310, 2007. © 2007 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>BMP</subject><subject>Body Patterning - genetics</subject><subject>Cells, Cultured</subject><subject>chordin</subject><subject>dorsal‐ventral patterning</subject><subject>Embryo, Nonmammalian</subject><subject>Freshwater</subject><subject>Glycoproteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Kupffer's vesicle</subject><subject>medaka</subject><subject>Mutation</subject><subject>Notochord</subject><subject>Oryzias - embryology</subject><subject>Oryzias - genetics</subject><subject>Oryzias latipes</subject><subject>Phenotype</subject><subject>Temperature</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9Lw0AQRxdRbK1e_ACSkwchdSbJZidHaesfKOhBBU_LdrNLo2lSs0kl397EFLzpaX6Hx4N5jJ0jTBEguE53aTsNMIj4ARsjJMIHFOKw35x8ColG7MS5dwCgOMJjNkIR80gEOGbiaW2Ksm63mfZUofLWZc4rrae8otyZ3NPrskqzwts0tSpqr18mVR_qlB1ZlTtztr8T9nK7eJ7d-8vHu4fZzdLXPEm4bxONPIpSbYnCOAysCQQpuzKarDGUKOACNHECRSj0irRCEYYqjtEISiGcsMvBu63Kz8a4Wm4yp02eq8KUjZMxIVCE-C8YQCgExdSBVwOoq9K5yli5rbKNqlqJIPuesu8pf3p28MXe2qy6x3_RfcAOwAH4ynLT_qGS89f52yD9BvzJf1g</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Takashima, Shigeo</creator><creator>Shimada, Atsuko</creator><creator>Kobayashi, Daisuke</creator><creator>Yokoi, Hayato</creator><creator>Narita, Takanori</creator><creator>Jindo, Tomoko</creator><creator>Kage, Takahiro</creator><creator>Kitagawa, Tadao</creator><creator>Kimura, Tetsuaki</creator><creator>Sekimizu, Koshin</creator><creator>Miyake, Akimitsu</creator><creator>Setiamarga, Davin H.E.</creator><creator>Murakami, Ryohei</creator><creator>Tsuda, Sachiko</creator><creator>Ooki, Shinya</creator><creator>Kakihara, Ken</creator><creator>Hojo, Motoki</creator><creator>Naruse, Kiyoshi</creator><creator>Mitani, Hiroshi</creator><creator>Shima, Akihiro</creator><creator>Ishikawa, Yuji</creator><creator>Araki, Kazuo</creator><creator>Saga, Yumiko</creator><creator>Takeda, Hiroyuki</creator><general>Wiley‐Liss, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Phenotypic analysis of a novel chordin mutant in medaka</title><author>Takashima, Shigeo ; Shimada, Atsuko ; Kobayashi, Daisuke ; Yokoi, Hayato ; Narita, Takanori ; Jindo, Tomoko ; Kage, Takahiro ; Kitagawa, Tadao ; Kimura, Tetsuaki ; Sekimizu, Koshin ; Miyake, Akimitsu ; Setiamarga, Davin H.E. ; Murakami, Ryohei ; Tsuda, Sachiko ; Ooki, Shinya ; Kakihara, Ken ; Hojo, Motoki ; Naruse, Kiyoshi ; Mitani, Hiroshi ; Shima, Akihiro ; Ishikawa, Yuji ; Araki, Kazuo ; Saga, Yumiko ; Takeda, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5995-f9c1544dcf883632fe278afbec8fee89a0570c8580a817cb8ca1733a661e78d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>BMP</topic><topic>Body Patterning - genetics</topic><topic>Cells, Cultured</topic><topic>chordin</topic><topic>dorsal‐ventral patterning</topic><topic>Embryo, Nonmammalian</topic><topic>Freshwater</topic><topic>Glycoproteins - genetics</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Kupffer's vesicle</topic><topic>medaka</topic><topic>Mutation</topic><topic>Notochord</topic><topic>Oryzias - embryology</topic><topic>Oryzias - genetics</topic><topic>Oryzias latipes</topic><topic>Phenotype</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takashima, Shigeo</creatorcontrib><creatorcontrib>Shimada, Atsuko</creatorcontrib><creatorcontrib>Kobayashi, Daisuke</creatorcontrib><creatorcontrib>Yokoi, Hayato</creatorcontrib><creatorcontrib>Narita, Takanori</creatorcontrib><creatorcontrib>Jindo, Tomoko</creatorcontrib><creatorcontrib>Kage, Takahiro</creatorcontrib><creatorcontrib>Kitagawa, Tadao</creatorcontrib><creatorcontrib>Kimura, Tetsuaki</creatorcontrib><creatorcontrib>Sekimizu, Koshin</creatorcontrib><creatorcontrib>Miyake, Akimitsu</creatorcontrib><creatorcontrib>Setiamarga, Davin H.E.</creatorcontrib><creatorcontrib>Murakami, Ryohei</creatorcontrib><creatorcontrib>Tsuda, Sachiko</creatorcontrib><creatorcontrib>Ooki, Shinya</creatorcontrib><creatorcontrib>Kakihara, Ken</creatorcontrib><creatorcontrib>Hojo, Motoki</creatorcontrib><creatorcontrib>Naruse, Kiyoshi</creatorcontrib><creatorcontrib>Mitani, Hiroshi</creatorcontrib><creatorcontrib>Shima, Akihiro</creatorcontrib><creatorcontrib>Ishikawa, Yuji</creatorcontrib><creatorcontrib>Araki, Kazuo</creatorcontrib><creatorcontrib>Saga, Yumiko</creatorcontrib><creatorcontrib>Takeda, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takashima, Shigeo</au><au>Shimada, Atsuko</au><au>Kobayashi, Daisuke</au><au>Yokoi, Hayato</au><au>Narita, Takanori</au><au>Jindo, Tomoko</au><au>Kage, Takahiro</au><au>Kitagawa, Tadao</au><au>Kimura, Tetsuaki</au><au>Sekimizu, Koshin</au><au>Miyake, Akimitsu</au><au>Setiamarga, Davin H.E.</au><au>Murakami, Ryohei</au><au>Tsuda, Sachiko</au><au>Ooki, Shinya</au><au>Kakihara, Ken</au><au>Hojo, Motoki</au><au>Naruse, Kiyoshi</au><au>Mitani, Hiroshi</au><au>Shima, Akihiro</au><au>Ishikawa, Yuji</au><au>Araki, Kazuo</au><au>Saga, Yumiko</au><au>Takeda, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic analysis of a novel chordin mutant in medaka</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2007-08</date><risdate>2007</risdate><volume>236</volume><issue>8</issue><spage>2298</spage><epage>2310</epage><pages>2298-2310</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over‐bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits variability of phenotypes, depending on the culture temperature, from embryos with a slightly ventralized phenotype to those without any head and trunk structures. Taking advantages of these variable and severe phenotypes, we analyzed the role of Chordin‐dependent tissues such as the notochord and Kupffer's vesicle (KV) in the establishment of left–right axis in fish. The results demonstrate that, in the absence of the notochord and KV, the medaka lateral plate mesoderm autonomously and bilaterally expresses spaw gene in a default state. Developmental Dynamics 236:2298–2310, 2007. © 2007 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley‐Liss, Inc</pub><pmid>17654721</pmid><doi>10.1002/dvdy.21245</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals BMP Body Patterning - genetics Cells, Cultured chordin dorsal‐ventral patterning Embryo, Nonmammalian Freshwater Glycoproteins - genetics Intercellular Signaling Peptides and Proteins - genetics Kupffer's vesicle medaka Mutation Notochord Oryzias - embryology Oryzias - genetics Oryzias latipes Phenotype Temperature |
| title | Phenotypic analysis of a novel chordin mutant in medaka |
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