A Synthesis of the Welwistatin Core

A Synthesis of the Welwistatin Core

An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels−Alder reaction, with indole serving as the tether between diene and dienophile, to form the natural product's characteristic bicyclo[4.3.1]decane...

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Veröffentlicht in:Organic letters 2006-11, Vol.8 (23), p.5287-5289
Hauptverfasser: Lauchli, Ryan, Shea, Kenneth J
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemical synthesis
Antineoplastic Agents - chemical synthesis
Indole Alkaloids
Models, Molecular
Molecular Structure
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Zusammenfassung:An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels−Alder reaction, with indole serving as the tether between diene and dienophile, to form the natural product's characteristic bicyclo[4.3.1]decane skeleton.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0620747