Pilot dose‐finding and safety study of bivalirudin in infants <6 months of age with thrombosis

Background: Thrombosis is not uncommon in children with serious medical conditions. Unfractionated heparin, the most commonly used anticoagulant in the acute management of thrombosis, has significant pharmacologic limitations, especially in infants. Newer anticoagulants have improved properties rela...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2007-08, Vol.5 (8), p.1654-1659
Hauptverfasser:	YOUNG, G., TARANTINO, M. D., WOHRLEY, J., WEBER, L. C., BELVEDERE, M., NUGENT, D. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - administration & dosage anticoagulation bivalirudin direct thrombin inhibitors Female Hirudins - administration & dosage Humans Infant Infant, Newborn Male Partial Thromboplastin Time pediatric Peptide Fragments - administration & dosage Pilot Projects Prospective Studies Recombinant Proteins - administration & dosage thrombosis Thrombosis - drug therapy Treatment Outcome
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Beschreibung
Zusammenfassung:	Background: Thrombosis is not uncommon in children with serious medical conditions. Unfractionated heparin, the most commonly used anticoagulant in the acute management of thrombosis, has significant pharmacologic limitations, especially in infants. Newer anticoagulants have improved properties relative to heparin, and this may enhance the outcome in children.Objective: To determine dosing, and to assess the safety and efficacy of bivairudin for infants with thrombosis.Methods: Infants
ISSN:	1538-7933 1538-7836 1538-7836
DOI:	10.1111/j.1538-7836.2007.02623.x