Efficient Preparation of Proline N-Carboxyanhydride Using Polymer-Supported Bases

A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of...

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Veröffentlicht in:	Organic letters 2006-11, Vol.8 (23), p.5385-5388
Hauptverfasser:	Gulín, Oscar P, Rabanal, Francesc, Giralt, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhydrides - chemical synthesis Molecular Structure Polymers - chemistry Proline - analogs & derivatives Proline - chemical synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0622965