Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

Cells are equipped with a number of transcriptional factors that safeguard against various environmental insults. Proteasomal protein degradation plays an important role in the Keap1-Nrf2 cytoprotection system, with molecular machinery similar to that for other environmental defense systems such as...

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Veröffentlicht in:	Biological chemistry 2006-10, Vol.387 (10/11), p.1311-1320
Hauptverfasser:	Tong, Kit I., Kobayashi, Akira, Katsuoka, Fumiki, Yamamoto, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CUL3-BTB E3 ligase DLG motif ETGE motif Humans Intracellular Signaling Peptides and Proteins - metabolism Keap1 Models, Biological NF-E2-Related Factor 2 - metabolism Nrf2 oxidative stress sensor Proteasome Endopeptidase Complex - metabolism Protein Binding Substrate Specificity
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