Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

A combination of benzoxazole, phenoxyalkyl side chain and phenoxybutyric acids was identified as highly potent and selective h-PPARα agonists. The synthesis, SAR studies and in vivo activities of the representative compounds are described. A combination of benzoxazole, phenoxyalkyl side chain, and p...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-08, Vol.17 (16), p.4689-4693
Hauptverfasser:	Yamazaki, Yukiyoshi, Abe, Kazutoyo, Toma, Tsutomu, Nishikawa, Masahiro, Ozawa, Hidefumi, Okuda, Ayumu, Araki, Takaaki, Oda, Soichi, Inoue, Keisuke, Shibuya, Kimiyuki, Staels, Bart, Fruchart, Jean-Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Animals Antigens, Plant Biological and medical sciences Design Drug Design Fibrates General and cellular metabolism. Vitamins HDL-cholesterol Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Humans Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Lipid abnormalities Medical sciences Mice Mice, Transgenic Molecular Structure Nuclear receptor Pharmacology. Drug treatments Plant Proteins PPAR alpha - agonists PPARα PPARα-selective Rats Rats, Sprague-Dawley Structure-Activity Relationship Synthesis Triglyceride
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