Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

A combination of benzoxazole, phenoxyalkyl side chain and phenoxybutyric acids was identified as highly potent and selective h-PPARα agonists. The synthesis, SAR studies and in vivo activities of the representative compounds are described. A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.