Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues

Seven known abietane diterpenoids and 11- O- and 12- O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SARs) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids wer...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-08, Vol.14 (15), p.5285-5291
Hauptverfasser:	Aoyagi, Yutaka, Takahashi, Yoshinao, Satake, Yudai, Takeya, Koichi, Aiyama, Ritsuo, Matsuzaki, Takeshi, Hashimoto, Shusuke, Kurihara, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abietane diterpenoids Animals Biological and medical sciences Carnosic acid Cell Line, Tumor Cell Proliferation - drug effects Cytotoxicity Diterpenes, Abietane - chemistry Diterpenes, Abietane - isolation & purification Diterpenes, Abietane - pharmacology Drug Screening Assays, Antitumor General pharmacology Lamiaceae - chemistry Leukemia P388 - drug therapy Medical sciences Mice Molecular Conformation P388 murine leukemia cells Perovskia abrotanoides Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry SAR Semisynthesis Stereoisomerism Structure-Activity Relationship Tumor Cells, Cultured
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Zusammenfassung:	Seven known abietane diterpenoids and 11- O- and 12- O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SARs) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells. Seven known abietane diterpenoids and 11- O- and 12- O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2006.03.047