A diversity oriented synthesis of 3′- O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’

A diversity oriented synthesis of 3′- O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’

The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis.

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Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2006-08, Vol.16 (15), p.3902-3905
Hauptverfasser: Lu, Genliang, Burgess, Kevin
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates. Nucleosides and nucleotides
Chemistry
DNA
Exact sciences and technology
Nucleoside
Nucleosides, nucleotides and oligonucleotides
Nucleotides - chemical synthesis
Organic chemistry
Photolabile
Preparations and properties
Sequence Analysis, DNA - methods
Sequencing
Triphosphate
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Beschreibung
Zusammenfassung:The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.05.035