Treatment of a Nonhealing Saphenous Vein Harvest Graft with Treprostinil Sodium

Impaired healing of saphenous vein harvest sites is a serious but under-recognized complication of coronary artery bypass grafting surgery, particularly in the presence of peripheral arterial disease. We report the use of a continuous subcutaneous infusion of treprostinil sodium, an analog of prosta...

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Veröffentlicht in:	The Annals of thoracic surgery 2008-04, Vol.85 (4), p.e20-e22
Hauptverfasser:	Zwicke, Dianne, MD, Buggy, Brian, MD, Lobacz, Don, BSN, Rollins, Kristan, PharmD, Strootman, Deborah, BSN
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arterial Occlusive Diseases - complications Cardiothoracic Surgery Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary Disease - diagnosis Coronary Disease - etiology Coronary Disease - surgery Epoprostenol - administration & dosage Epoprostenol - analogs & derivatives Humans Infusions, Intravenous Injections, Subcutaneous Male Peripheral Vascular Diseases - complications Postoperative Complications - diagnosis Postoperative Complications - drug therapy Risk Assessment Saphenous Vein - transplantation Surgery Tissue and Organ Harvesting - adverse effects Tissue and Organ Harvesting - methods Treatment Outcome Wound Healing - drug effects Wounds and Injuries - drug therapy Wounds and Injuries - etiology
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Zusammenfassung:	Impaired healing of saphenous vein harvest sites is a serious but under-recognized complication of coronary artery bypass grafting surgery, particularly in the presence of peripheral arterial disease. We report the use of a continuous subcutaneous infusion of treprostinil sodium, an analog of prostacyclin, to treat a limb-threatening, nonhealing saphenous vein harvest incision site after myocardial revascularization.
ISSN:	0003-4975 1552-6259
DOI:	10.1016/j.athoracsur.2007.11.059