Microprocessor controlled transdermal drug delivery

Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, p...

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Veröffentlicht in:	International journal of pharmaceutics 2006-07, Vol.317 (1), p.1-6
Hauptverfasser:	Subramony, J. Anand, Sharma, Ashutosh, Phipps, J.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Analgesics, Opioid - administration & dosage Anesthetics, Local - administration & dosage Biological and medical sciences Controller Drug delivery Drug Delivery Systems Fentanyl Fentanyl - administration & dosage General pharmacology Humans Iontophoresis Lidocaine Lidocaine - administration & dosage Medical sciences Microcomputers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Transdermal
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Beschreibung
Zusammenfassung:	Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2006.03.053