Prothrombotic Gene Expression Profile in Vascular Smooth Muscle Cells of Human Saphenous Vein, but Not Internal Mammary Artery

BACKGROUND—The resistance of internal mammary artery (IMA) toward thrombotic occlusion and accelerated atherosclerosis is not well understood. This study analyzed gene expression profiles of vascular smooth muscle cells (VSMCs) from IMA versus saphenous vein (SV). METHODS AND RESULTS—54′675 probe se...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2008-04, Vol.28 (4), p.705-710
Hauptverfasser:	Payeli, S K, Latini, R, Gebhard, C, Patrignani, A, Wagner, U, Lüscher, T F, Tanner, F C
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - genetics Biological and medical sciences Blood and lymphatic vessels Blood Coagulation - genetics Blood vessels and receptors Cardiology. Vascular system Coronary Artery Bypass Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Gene Expression Profiling Graft Occlusion, Vascular - etiology Graft Occlusion, Vascular - genetics Humans Lipoproteins - genetics Mammary Arteries - cytology Mammary Arteries - metabolism Mammary Arteries - transplantation Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism Oligonucleotide Array Sequence Analysis Plasminogen Activator Inhibitor 1 - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Saphenous Vein - cytology Saphenous Vein - metabolism Saphenous Vein - transplantation Thromboplastin - genetics Thrombosis - etiology Thrombosis - genetics Tissue Distribution Tissue Plasminogen Activator - genetics Transplantation, Autologous Vertebrates: cardiovascular system
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Zusammenfassung:	BACKGROUND—The resistance of internal mammary artery (IMA) toward thrombotic occlusion and accelerated atherosclerosis is not well understood. This study analyzed gene expression profiles of vascular smooth muscle cells (VSMCs) from IMA versus saphenous vein (SV). METHODS AND RESULTS—54′675 probe sets were examined by Affymetrix microarrays. Thirty-one genes belonged to the coagulation system; 2 were differentially expressed, namely tissue factor (TF) and tissue-type plasminogen activator (tPA). TF was 3.1-fold lower in IMA than SV (P=0.006), whereas tPA was 9.0-fold higher (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.107.155333