Sirolimus-Eluting Stents at Two Years: A Pooled Analysis of SIRIUS, E-SIRIUS, and C-SIRIUS With Emphasis on Late Revascularizations and Stent Thromboses

Sirolimus-Eluting Stents at Two Years: A Pooled Analysis of SIRIUS, E-SIRIUS, and C-SIRIUS With Emphasis on Late Revascularizations and Stent Thromboses

Prospective follow-up at 2 years was obtained for 98.7% of the pooled 1,510 patients enrolled in SIRIUS, E-SIRIUS and C-SIRIUS, 3 randomized controlled trials that compared sirolimus-eluting stents (SESs) with bare metal stents (BMSs) to treat long stenoses in small coronary arteries. By 720 days, c...

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Veröffentlicht in:The American journal of cardiology 2006-07, Vol.98 (1), p.36-41
Hauptverfasser: Schampaert, Erick, Moses, Jeffrey W., Schofer, Joachim, Schlüter, Michael, Gershlick, Anthony H., Cohen, Eric A., Palisaitis, Donald A., Breithardt, Günter, Donohoe, Dennis J., Wang, Hong, Popma, Jeffrey J., Kuntz, Richard E., Leon, Martin B.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood clots
Cardiology. Vascular system
Clinical trials
Comparative studies
Coronary Artery Disease - drug therapy
Coronary Artery Disease - surgery
Coronary vessels
Equipment Design
Female
Follow-Up Studies
Humans
Immunosuppressive Agents - administration & dosage
Male
Medical sciences
Middle Aged
Myocardial Revascularization
Prospective Studies
Randomized Controlled Trials as Topic
Sirolimus - administration & dosage
Stents
Stents - adverse effects
Thrombosis - etiology
Treatment Outcome
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Zusammenfassung:Prospective follow-up at 2 years was obtained for 98.7% of the pooled 1,510 patients enrolled in SIRIUS, E-SIRIUS and C-SIRIUS, 3 randomized controlled trials that compared sirolimus-eluting stents (SESs) with bare metal stents (BMSs) to treat long stenoses in small coronary arteries. By 720 days, clinically driven target lesion revascularizations were performed in 5.7% of patients with SESs versus 22.6% of patients with BMSs (risk ratio 0.25, 95% confidence interval 0.18 to 0.35, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2006.01.049