An Efficient Synthesis of Gougerotin and Related Analogues Using Solid- and Solution-Phase Methodology

The first solid-phase synthesis of the natural product gougerotin has been accomplished. The synthetic route is versatile and allows for diversification at position C-4 of the heterocycle, C-6‘ of the sugar ring, and both residues of the peptidic moiety at N-4‘ in a parallel fashion.

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Veröffentlicht in:	Organic letters 2005-08, Vol.7 (16), p.3429-3432
Hauptverfasser:	Migawa, Michael T, Risen, Lisa M, Griffey, Richard H, Swayze, Eric E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Biological Products - chemical synthesis Biological Products - pharmacology Candida albicans - drug effects Combinatorial Chemistry Techniques Escherichia coli - drug effects Pyrimidine Nucleosides - chemical synthesis Pyrimidine Nucleosides - pharmacology
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Beschreibung
Zusammenfassung:	The first solid-phase synthesis of the natural product gougerotin has been accomplished. The synthetic route is versatile and allows for diversification at position C-4 of the heterocycle, C-6‘ of the sugar ring, and both residues of the peptidic moiety at N-4‘ in a parallel fashion.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0507322