2,3-Disubstituted Benzofuran and Indole by Copper-Mediated C−C Bond Extension Reaction of 3-Zinciobenzoheterole
A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl2 produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-dis...
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| Veröffentlicht in: | Organic letters 2006-06, Vol.8 (13), p.2803-2805 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl2 produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-disubstituted benzofurans and indoles. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol060896y |