A New Synthetic Approach to Phenol Derivatives:  Use of Ring-Closing Olefin Metathesis

Phenol derivatives, which are one of the most important classes of aromatic compounds in organic chemistry, were synthesized by ruthenium-catalyzed ring-closing olefin metathesis (RCM) of 1,4,7-trien-3-ones with versatile substitution patterns. The RCM reaction for producing phenol derivatives was also successful with 1,5,7-trien-3-one as another precursor. Most of the phenols prepared here could not be obtained easily by conventional methods.