Peripheral blood gene expression profiling in rheumatoid arthritis

We carried out gene expression profiling of peripheral blood mononuclear cells (PBMCs) in 29 patients with active rheumatoid arthritis (RA) and 21 control subjects using Affymetrix U95Av2 arrays. Using cluster analysis, we observed a significant alteration in the expression pattern of 81 genes ( P

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Bibliographische Detailangaben
Veröffentlicht in:	Genes and immunity 2005-08, Vol.6 (5), p.388-397
Hauptverfasser:	Batliwalla, F M, Baechler, E C, Xiao, X, Li, W, Balasubramanian, S, Khalili, H, Damle, A, Ortmann, W A, Perrone, A, Kantor, A B, Gulko, P S, Kern, M, Furie, R, Behrens, T W, Gregersen, P K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Biomedical and Life Sciences Biomedicine Cancer Research Cells, Cultured Diagnosis DNA testing Female full-paper Gene Expression Gene Expression Profiling - methods Gene Expression Regulation - genetics Genetic aspects Genomics Grb2 protein Human Genetics Humans Immunology Interleukin 1 Interleukin 1 receptor antagonist Intracellular Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - pathology Male Methods Middle Aged Monocytes Oligonucleotide Array Sequence Analysis Pathogenesis Peripheral blood mononuclear cells Phosphatase Physiological aspects Population studies Protein-tyrosine-phosphatase Rheumatoid arthritis S100A8 protein S100A9 protein Signal Transduction - genetics
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Beschreibung
Zusammenfassung:	We carried out gene expression profiling of peripheral blood mononuclear cells (PBMCs) in 29 patients with active rheumatoid arthritis (RA) and 21 control subjects using Affymetrix U95Av2 arrays. Using cluster analysis, we observed a significant alteration in the expression pattern of 81 genes ( P
ISSN:	1466-4879 1476-5470
DOI:	10.1038/sj.gene.6364209