The prognosis of hearing impairment complicating HIV-negative cryptococcal meningitis

Eight patients who had sensorineural hearing loss (SNHL) associated with cryptococcal meningitis were studied. After a minimum 3-year follow-up, one had died. Among the seven survivors, three had improved, two stabilized, and two progressed. Predictive factors included visual disturbance, meningeal...

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Veröffentlicht in:	Neurology 2005-07, Vol.65 (2), p.320-322
Hauptverfasser:	WANG, H.-C, CHANG, W.-N, LUI, C.-C, PENG, J.-P, HUANG, C.-R, CHANG, H.-W, LILIANG, P.-C, LU, C.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens, Fungal - cerebrospinal fluid Antiviral agents Arachnoiditis - complications Arachnoiditis - pathology Arachnoiditis - physiopathology Audiometry Biological and medical sciences Cochlea - pathology Cochlea - physiopathology Cochlear Nerve - pathology Cochlear Nerve - physiopathology Female Hearing Loss, Sensorineural - complications Hearing Loss, Sensorineural - diagnosis Hearing Loss, Sensorineural - pathology HIV Seronegativity Human viral diseases Humans Infectious diseases Magnetic Resonance Imaging Male Medical sciences Meninges - microbiology Meninges - pathology Meninges - physiopathology Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - diagnosis Middle Aged Neurology Optic Nerve - metabolism Optic Nerve - pathology Optic Nerve - physiopathology Pharmacology. Drug treatments Predictive Value of Tests Prognosis Survival Rate Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Vision Disorders - metabolism Vision Disorders - pathology Vision Disorders - physiopathology
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Zusammenfassung:	Eight patients who had sensorineural hearing loss (SNHL) associated with cryptococcal meningitis were studied. After a minimum 3-year follow-up, one had died. Among the seven survivors, three had improved, two stabilized, and two progressed. Predictive factors included visual disturbance, meningeal enhancements on MRI, and a CSF cryptococcal antigen titer of >1:1,024. SNHL accounted for 30.8% (8/26) of cryptococcal meningitis patients in our study.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000168904.41046.2b