Modeling the Parkinson's tremor and its treatments

In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also co...

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Veröffentlicht in:Journal of theoretical biology 2005-10, Vol.236 (3), p.311-322
Hauptverfasser: Haeri, Mohammad, Sarbaz, Yashar, Gharibzadeh, Shahriar
Format: Artikel
Sprache:eng
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Zusammenfassung:In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also considered. Medication or treatment of the disease both by drug prescription and electrical signal stimulation are modeled based on the same model introduced for the disease itself. Two new medication strategies are proposed based on the model to reduce the side effects caused by the present drug prescription.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2005.03.014