Alpha2-adrenergic receptor subtype-specific activation of NF-kappaB in PC12 cells

In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same sub...

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Veröffentlicht in:	Neuroscience letters 2006-07, Vol.402 (3), p.210-215
Hauptverfasser:	Lymperopoulos, Anastasios, Karkoulias, Georgios, Koch, Walter J, Flordellis, Christodoulos S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cyclin-Dependent Kinase Inhibitor p21 - genetics Humans Mitogen-Activated Protein Kinase 1 - physiology Mitogen-Activated Protein Kinase 3 - physiology NF-kappa B - genetics NF-kappa B - metabolism PC12 Cells Phosphatidylinositol 3-Kinases - physiology Rats Receptors, Adrenergic, alpha-2 - physiology Signal Transduction Transcription, Genetic
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Zusammenfassung:	In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manner (alpha2A
ISSN:	0304-3940