Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Converging on the goal: New chemistry enables the key Cys‐peptide‐(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligatio...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-06, Vol.45 (24), p.3985-3988
Hauptverfasser: Bang, Duhee, Pentelute, Brad L., Kent, Stephen B. H.
Format: Artikel
Sprache:eng
Schlagworte:
Kinetics
native chemical ligation
peptides
Peptides - chemistry
Plant Proteins - chemical synthesis
protein synthesis
Proteins - chemical synthesis
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Zusammenfassung:Converging on the goal: New chemistry enables the key Cys‐peptide‐(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200600702