A concise synthesis of (-)-centrolobine via a diastereoselective ring rearrangement metathesis-isomerisation sequence

A concise synthesis of (-)-centrolobine via a diastereoselective ring rearrangement metathesis-isomerisation sequence

A total synthesis of (-)-centrolobine (1) based on a diastereoselective ring rearrangement metathesis-double bond isomerisation sequence and a one-pot cross metathesis-hydrogenation procedure is described.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2006-01 (18), p.1968-1970
Hauptverfasser: Böhrsch, Verena, Blechert, Siegfried
Format: Artikel
Sprache:eng
Schlagworte:
Isomerism
Molecular Structure
Pyrans - chemical synthesis
Pyrans - chemistry
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Beschreibung
Zusammenfassung:A total synthesis of (-)-centrolobine (1) based on a diastereoselective ring rearrangement metathesis-double bond isomerisation sequence and a one-pot cross metathesis-hydrogenation procedure is described.
ISSN:1359-7345
1364-548X
DOI:10.1039/b602056a