Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines

Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines

The discovery, synthesis, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kinase inhibitors are discussed. The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kin...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2005-08, Vol.15 (16), p.3778-3781
Hauptverfasser: Alberti, Michael J., Auten, Elizabeth P., Lackey, Karen E., McDonald, Octerloney B., Wood, Edgar R., Preugschat, Frank, Cutler, Geoffrey J., Kane-Carson, Laurie, Liu, Wei, Jung, David K.
Format: Artikel
Sprache:eng
Schlagworte:
EGFR
ErB
GSK
Humans
Hydrogen Bonding
Kinase inhibitor
Molecular Structure
Protein Conformation
Protein Kinase Inhibitors - chemical synthesis
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - pharmacology
Protein Kinases - drug effects
Protein Structure, Tertiary
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Structure-Activity Relationship
VEGFR
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Zusammenfassung:The discovery, synthesis, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kinase inhibitors are discussed. The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kinase inhibitors are discussed.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.05.100