Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients

Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism, the aim of th...

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Veröffentlicht in:Atherosclerosis 2005-08, Vol.181 (2), p.403-405
Hauptverfasser: Pruneta-Deloche, Valérie, Ponsin, Gabriel, Groisne, Laure, Fruchart-Najib, Jamila, Lagarde, Michel, Moulin, Philippe
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Sprache:eng
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Zusammenfassung:Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism, the aim of the study was to determine the postprandial apoAV profile of Type 2 diabetic patients. We compared data from 11 patients with Type 2 diabetes mellitus to that of 12 non-diabetic normolipidemic subjects following the ingestion of a lipid-rich cream. Postprandial apoAV was elevated in diabetic patients but no correlation was observed either with plasma TG concentration or with the intensity of lipoprotein lipase-dependent lipolysis. These data obtained in human subjects suggest that plasma apoAV concentration does not play an acute or a direct role in the regulation of plasma TG in the postprandial state.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2005.01.034