A Toll for lupus
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a r...
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| Veröffentlicht in: | Lupus 2005-01, Vol.14 (6), p.417-422 |
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| creator | Anders, H-J |
| description | Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA? |
| doi_str_mv | 10.1191/0961203305lu2102rr |
| format | Article |
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TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1191/0961203305lu2102rr</identifier><identifier>PMID: 16038103</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Antigens ; Autoimmunity ; CpG Islands - immunology ; Cytokines ; Dendritic cells ; DNA Methylation ; Humans ; Immunity, Innate ; Ligands ; Lupus ; Lupus Erythematosus, Systemic - etiology ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - therapy ; Lymphocytes ; Membrane Glycoproteins - immunology ; Models, Immunological ; Oligodeoxyribonucleotides - therapeutic use ; Pathogenesis ; Pathogens ; Receptors, Cell Surface - immunology ; Signal Transduction ; Toll-Like Receptor 9 ; Toll-Like Receptors ; Vaccines</subject><ispartof>Lupus, 2005-01, Vol.14 (6), p.417-422</ispartof><rights>2005 Arnold</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-5da54ef6b7211d94c580070e7f00d37fe50f013f4901df31dfba59453ad9bfc43</citedby><cites>FETCH-LOGICAL-c509t-5da54ef6b7211d94c580070e7f00d37fe50f013f4901df31dfba59453ad9bfc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1191/0961203305lu2102rr$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1191/0961203305lu2102rr$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16038103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anders, H-J</creatorcontrib><title>A Toll for lupus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?</description><subject>Antigens</subject><subject>Autoimmunity</subject><subject>CpG Islands - immunology</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>DNA Methylation</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Ligands</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - etiology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - therapy</subject><subject>Lymphocytes</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Models, Immunological</subject><subject>Oligodeoxyribonucleotides - therapeutic use</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Signal Transduction</subject><subject>Toll-Like Receptor 9</subject><subject>Toll-Like Receptors</subject><subject>Vaccines</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0L9LAzEUB_Agiq1VcHaQw8Ht7HvJJbmMpfgLCi51Drm7RFrSXk2awf_elBYKCjqEDPm8b3hfQm4QHhAVjkEJpMAYcJ8oAg3hhAyxkrLML_SUDHeg3IkBuYhxCQAMlTgnAxTAagQ2JNeTYt57X7g-FD5tUrwkZ874aK8O94i8Pz3Opy_l7O35dTqZlS0HtS15Z3hlnWgkRexU1fIaQIKVDqBj0lkODpC5SgF2juXTGK4qzkynGtdWbETu97mb0H8mG7d6tYit9d6sbZ-iFjUILjn_F6LkAmquMrz7AZd9Cuu8hKaUCmSK0YzoHrWhjzFYpzdhsTLhSyPoXav6d6t56PaQnJqV7Y4jhxozGO9BNB_2-O0fkd_05H3C</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Anders, H-J</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>A Toll for lupus</title><author>Anders, H-J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-5da54ef6b7211d94c580070e7f00d37fe50f013f4901df31dfba59453ad9bfc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antigens</topic><topic>Autoimmunity</topic><topic>CpG Islands - immunology</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>DNA Methylation</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Ligands</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - etiology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - therapy</topic><topic>Lymphocytes</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Models, Immunological</topic><topic>Oligodeoxyribonucleotides - therapeutic use</topic><topic>Pathogenesis</topic><topic>Pathogens</topic><topic>Receptors, Cell Surface - immunology</topic><topic>Signal Transduction</topic><topic>Toll-Like Receptor 9</topic><topic>Toll-Like Receptors</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anders, H-J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anders, H-J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Toll for lupus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>14</volume><issue>6</issue><spage>417</spage><epage>422</epage><pages>417-422</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>16038103</pmid><doi>10.1191/0961203305lu2102rr</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2005-01, Vol.14 (6), p.417-422 |
| issn | 0961-2033 1477-0962 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Antigens Autoimmunity CpG Islands - immunology Cytokines Dendritic cells DNA Methylation Humans Immunity, Innate Ligands Lupus Lupus Erythematosus, Systemic - etiology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - therapy Lymphocytes Membrane Glycoproteins - immunology Models, Immunological Oligodeoxyribonucleotides - therapeutic use Pathogenesis Pathogens Receptors, Cell Surface - immunology Signal Transduction Toll-Like Receptor 9 Toll-Like Receptors Vaccines |
| title | A Toll for lupus |
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