A Toll for lupus

Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a r...

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Veröffentlicht in:	Lupus 2005-01, Vol.14 (6), p.417-422
1. Verfasser:	Anders, H-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoimmunity CpG Islands - immunology Cytokines Dendritic cells DNA Methylation Humans Immunity, Innate Ligands Lupus Lupus Erythematosus, Systemic - etiology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - therapy Lymphocytes Membrane Glycoproteins - immunology Models, Immunological Oligodeoxyribonucleotides - therapeutic use Pathogenesis Pathogens Receptors, Cell Surface - immunology Signal Transduction Toll-Like Receptor 9 Toll-Like Receptors Vaccines
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Beschreibung
Zusammenfassung:	Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?
ISSN:	0961-2033 1477-0962
DOI:	10.1191/0961203305lu2102rr