A new approach to phospholipid synthesis using tetrahydropyranyl glycerol: rapid access to phosphatidic acid and phosphatidylcholine, including mixed-chain glycerophospholipid derivatives

A new synthesis of phosphatidic acid and phosphatidylcholine is reported, relying on the preparation of 3-tetrahydropyranyl-sn-glycerol as the key intermediate for sequential introduction of the primary and secondary acyl functions to produce chiral diglycerides that are phosphorylated to obtain the...

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Veröffentlicht in:	Organic & biomolecular chemistry 2006-01, Vol.4 (12), p.2358-2360
Hauptverfasser:	Rosseto, Renato, Bibak, Niloufar, Hajdu, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Glycerol - analogs & derivatives Glycerol - chemistry Glycerophospholipids - chemical synthesis Phosphatidic Acids - chemical synthesis Phosphatidylcholines - chemical synthesis Phospholipids - chemical synthesis Phosphorylation
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Beschreibung
Zusammenfassung:	A new synthesis of phosphatidic acid and phosphatidylcholine is reported, relying on the preparation of 3-tetrahydropyranyl-sn-glycerol as the key intermediate for sequential introduction of the primary and secondary acyl functions to produce chiral diglycerides that are phosphorylated to obtain the target phospholipid compounds.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b603788g