Reversing the Discovery Paradigm:  A New Approach to the Combinatorial Discovery of Fluorescent Chemosensors

Reversing the Discovery Paradigm:  A New Approach to the Combinatorial Discovery of Fluorescent Chemosensors

We report here a new approach to the discovery of fluorescent chemosensors in which a new signaling mechanism allows a core fluorophore to be used in a combinatorial search for new binding events, thus reversing the reigning discovery paradigm.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Chemical Society 2005-07, Vol.127 (29), p.10124-10125
Hauptverfasser: Mello, Jesse V, Finney, Nathaniel S
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemical synthesis
Amino Acids - chemistry
Analytical chemistry
Biosensing Techniques
Cations, Divalent
Chemistry
Exact sciences and technology
Fluorenes - chemical synthesis
Fluorenes - chemistry
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
General, instrumentation
Mercury - analysis
Mercury - chemistry
Pyridines - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We report here a new approach to the discovery of fluorescent chemosensors in which a new signaling mechanism allows a core fluorophore to be used in a combinatorial search for new binding events, thus reversing the reigning discovery paradigm.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja043682p