High-Resolution Magic Angle Spinning NMR of the Neuronal Tau Protein Integrated in Alzheimer's-Like Paired Helical Fragments

HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2005-07, Vol.127 (29), p.10138-10139
Hauptverfasser:	Sillen, Alain, Wieruszeski, Jean-Michel, Leroy, Arnaud, Younes, Amena Ben, Landrieu, Isabelle, Lippens, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Analytical, structural and metabolic biochemistry Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology General aspects, investigation methods Intermediate Filaments - chemistry Intermediate Filaments - metabolism Medical sciences Molecular biophysics Neurology Nuclear Magnetic Resonance, Biomolecular - methods Protein Structure, Secondary Protein Structure, Tertiary Proteins Spectroscopy : techniques and spectras tau Proteins - chemistry tau Proteins - metabolism
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Beschreibung
Zusammenfassung:	HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0516211