Impaired antiatherogenic function of high-density lipoproteins in the presence of various risk factors for coronary heart disease

We studied acception of cholesterol from Fu5AH hepatoma cells by blood serum from subjects with normal level of high-density lipoprotein cholesterol and hyperlipidemia (alone or in combination with other risk factors for coronary heart disease). Cholesterol-binding activity of high-density lipoprote...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-03, Vol.139 (3), p.290-292
Hauptverfasser:	Serdyuk, A P, Ozerova, I N, Kamyshova, T V, Perova, N V, Metel'skaya, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Pressure Body Mass Index Body Weight Carcinoma, Hepatocellular - metabolism Cholesterol - blood Cholesterol - metabolism Cholesterol, HDL - blood Cholesterol, HDL - metabolism Coronary Disease - blood Coronary Disease - etiology Coronary Disease - prevention & control Humans Hyperlipidemias - complications Liver Neoplasms - metabolism Male Middle Aged Risk Factors Tumor Cells, Cultured Urban Population
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Zusammenfassung:	We studied acception of cholesterol from Fu5AH hepatoma cells by blood serum from subjects with normal level of high-density lipoprotein cholesterol and hyperlipidemia (alone or in combination with other risk factors for coronary heart disease). Cholesterol-binding activity of high-density lipoproteins decreased in subjects with hyperlipidemia alone or in combination with excess body weight and/or arterial hypertension. Impairment of high-density lipoprotein activity was associated with changes in their phospholipid composition.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0274-6