Simvastatin and preparation of polyunsaturated phospholipids produce similar changes in the phospholipid composition of high-density lipoproteins during hypercholesterolemia

We studied the phospholipid composition of high-density lipoproteins in patients with coronary heart disease and hypercholesterolemia treated with simvastatin (Zocor, inhibitor of the key enzyme of cholesterol synthesis) and preparation of polyunsaturated phospholipids (lipostabil forte). Simvastati...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-02, Vol.139 (2), p.210-212
Hauptverfasser:	Ozerova, I N, Akhmedzhanov, N M, Perova, N V, Paramonova, I V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anticholesteremic Agents - therapeutic use Coronary Disease - complications Humans Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - etiology Lipoproteins, HDL - blood Lipoproteins, HDL - chemistry Middle Aged Phosphatidylcholines - therapeutic use Phospholipids - analysis Phospholipids - blood Simvastatin - therapeutic use
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Zusammenfassung:	We studied the phospholipid composition of high-density lipoproteins in patients with coronary heart disease and hypercholesterolemia treated with simvastatin (Zocor, inhibitor of the key enzyme of cholesterol synthesis) and preparation of polyunsaturated phospholipids (lipostabil forte). Simvastatin produced a hypolipidemic effect and modulates the phospholipid composition of high-density lipoproteins (similarly to lipostabil forte). These changes contribute to functional activity of high-density lipoproteins in the reverse cholesterol transport.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0250-1