Enantioselective total synthesis of bioactive natural product (+)-Sch 642305: a structurally novel inhibitor of bacterial DNA primase and HIV-1 Tat transactivation

The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-08 (29), p.3703-3705
Hauptverfasser:	Mehta, Goverdhan, Shinde, Harish M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology DNA Primase - antagonists & inhibitors DNA Primase - metabolism DNA, Bacterial - genetics Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Gene Products, tat - metabolism HIV-1 - genetics HIV-1 - metabolism Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology Molecular Structure Stereoisomerism tat Gene Products, Human Immunodeficiency Virus Transcriptional Activation - drug effects
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Beschreibung
Zusammenfassung:	The total synthesis of the bioactive natural product (+)-Sch 642305 has been achieved from a readily available chiral building block using an RCM protocol to construct the key decalactone moiety; our approach is notable for its built-in flexibility and is diversity oriented.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b505264e