Effects of bradysole and dibasole on cerebral bloodflow under experimental conditions

Bradysole (1 mg/kg intravenously) induced a moderate increase in cerebral bloodflow and a minor decrease in systemic blood pressure in narcotized rats. These effects were less pronounced compared to the effects of dibasole (bradysole structural analog) in the same dose.

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-03, Vol.139 (3), p.322-323
Hauptverfasser:	Galenko-Yaroshevskii, P A, Turovaya, A Yu, Uvarov, A V, Ivashev, M N, Arl't, A V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzimidazoles - pharmacology Blood Pressure - drug effects Blood Pressure - physiology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dose-Response Relationship, Drug Male Neurotransmitter Agents - chemistry Neurotransmitter Agents - pharmacology Rats Rats, Wistar Sulfhydryl Compounds - pharmacology Time Factors
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Beschreibung
Zusammenfassung:	Bradysole (1 mg/kg intravenously) induced a moderate increase in cerebral bloodflow and a minor decrease in systemic blood pressure in narcotized rats. These effects were less pronounced compared to the effects of dibasole (bradysole structural analog) in the same dose.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0283-5