Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats
We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2005-04, Vol.139 (4), p.418-420 |
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| container_end_page | 420 |
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| container_issue | 4 |
| container_start_page | 418 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 139 |
| creator | Galenko-Yaroshevskii, A P Turovaya, A Yu Uvarov, A V Prikhod'ko, A K Ivashev, M N Arl't, A V Anisimova, V A |
| description | We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose. |
| doi_str_mv | 10.1007/s10517-005-0310-6 |
| format | Article |
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| subjects | Animals Benzimidazoles - pharmacology Cerebrovascular Circulation - drug effects Dose-Response Relationship, Drug Lidocaine - pharmacology Male Rats Rats, Wistar |
| title | Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats |
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