Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats

We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-04, Vol.139 (4), p.418-420
Hauptverfasser:	Galenko-Yaroshevskii, A P, Turovaya, A Yu, Uvarov, A V, Prikhod'ko, A K, Ivashev, M N, Arl't, A V, Anisimova, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzimidazoles - pharmacology Cerebrovascular Circulation - drug effects Dose-Response Relationship, Drug Lidocaine - pharmacology Male Rats Rats, Wistar
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0310-6