C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia

The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-04, Vol.139 (4), p.421-423
Hauptverfasser:	Fadyukova, O E, Kadi, A, Bai, Ou, Andzhusheva, G M, Koshelev, V B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - prevention & control Neuroprotective Agents - pharmacology Oligopeptides - pharmacology Proline - analogs & derivatives Proline - pharmacology Rats
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0311-5