Osteoclasts eat stem cells out of house and home

Osteoclasts carve out the marrow space where hematopoietic stem cells reside, but they have been considered bystanders during hematopoiesis. Osteoclasts are now shown to mediate stem cell mobilization, enabling stem cell emigration from the marrow to the circulation.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2006-06, Vol.12 (6), p.610-611
Hauptverfasser:	Purton, Louise E, Scadden, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Carrier Proteins - genetics Carrier Proteins - metabolism Cell adhesion & migration Cell Movement - physiology Emigration Hematopoiesis - physiology Hematopoietic Stem Cells - metabolism Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Osteoclasts - metabolism RANK Ligand Receptor Activator of Nuclear Factor-kappa B Stem cells
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Beschreibung
Zusammenfassung:	Osteoclasts carve out the marrow space where hematopoietic stem cells reside, but they have been considered bystanders during hematopoiesis. Osteoclasts are now shown to mediate stem cell mobilization, enabling stem cell emigration from the marrow to the circulation.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm0606-610