Role of Na/K-ATPase in regulation of neurite growth in sensory neurons

We studied the effects of acetylcholine and norepinephrine on the growth of neurites in organotypic culture of 10-12-day-old chick embryo sensory neurons. Acetylcholine (10(-8) M) and norepinephrine (10(-13) M) stimulated the growth on sensory neuron neurites. Experiments with combined application o...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-02, Vol.139 (2), p.190-192
Hauptverfasser:	Penniyainen, V A, Lopatina, E V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Cells, Cultured Chick Embryo Neurites - drug effects Neurites - enzymology Neurons, Afferent - drug effects Neurons, Afferent - enzymology Norepinephrine - pharmacology Ouabain - pharmacology Sodium-Potassium-Exchanging ATPase - metabolism Sodium-Potassium-Exchanging ATPase - physiology
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Beschreibung
Zusammenfassung:	We studied the effects of acetylcholine and norepinephrine on the growth of neurites in organotypic culture of 10-12-day-old chick embryo sensory neurons. Acetylcholine (10(-8) M) and norepinephrine (10(-13) M) stimulated the growth on sensory neuron neurites. Experiments with combined application of acetylcholine and norepinephrine against the background of ouabain showed that the nonspecific action of the test neurotransmitters is related to modulation of Na/K-ATPase activity.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0244-z