A convenient gram-scale synthesis of uridine diphospho( 13C 6)glucose

A convenient gram-scale synthesis of uridine diphospho( 13C 6)glucose

A simple gram-scale synthesis of uridine diphospho( 13C 6)glucose is presented from d-( 13C 6)glucose. The critical step uses a 1 H-tetrazole-catalyzed coupling of 2,3,4,6-tetra- O-acetyl-α- d-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine diphospho( 13C 6)glucose was used in the struc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Carbohydrate research 2006-07, Vol.341 (10), p.1743-1747
Hauptverfasser: Dinev, Zoran, Wardak, Ahmad Z., Brownlee, Robert T.C., Williams, Spencer J.
Format: Artikel
Sprache:eng
Schlagworte:
beta-Glucans - chemistry
Carbon Isotopes
Glucan
Glucosephosphates - chemistry
Isotope Labeling - methods
Isotopic labeling
Lolium - chemistry
Morpholidate coupling
Sugar nucleotides
UDP-glucose
Uridine Diphosphate Glucose - chemical synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A simple gram-scale synthesis of uridine diphospho( 13C 6)glucose is presented from d-( 13C 6)glucose. The critical step uses a 1 H-tetrazole-catalyzed coupling of 2,3,4,6-tetra- O-acetyl-α- d-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine diphospho( 13C 6)glucose was used in the structural identification of (1→3)-β- d-glucan from Lolium multiflorum.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2006.02.033