Protein aggregation in crowded environments

Protein aggregation in crowded environments

The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon re...

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Veröffentlicht in:Biological chemistry 2006-05, Vol.387 (5), p.485-497
Hauptverfasser: Ellis, R. John, Minton, Allen P.
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Animals
excluded volume
Humans
macromolecular crowding
Macromolecular Substances - chemistry
Macromolecular Substances - metabolism
Models, Biological
Models, Molecular
molecular chaperones
Molecular Chaperones - chemistry
Molecular Chaperones - metabolism
protein aggregation
Protein Binding
Protein Denaturation
Protein Folding
Proteins - chemistry
Proteins - metabolism
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Beschreibung
Zusammenfassung:The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.
ISSN:1431-6730
1437-4315
DOI:10.1515/BC.2006.064