Novel One-Pot Total Syntheses of Deoxyvasicinone, Mackinazolinone, Isaindigotone, and Their Derivatives Promoted by Microwave Irradiation

Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process...

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Veröffentlicht in:	Organic letters 2005-07, Vol.7 (15), p.3363-3366
Hauptverfasser:	Liu, Ji-Feng, Ye, Ping, Sprague, Kevin, Sargent, Katie, Yohannes, Daniel, Baldino, Carmen M, Wilson, Christopher J, Ng, Shi-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Microwaves Molecular Structure Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolinones Radiation
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Zusammenfassung:	Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0513084