Regulation of the Wnt/β-catenin pathway by redox signaling

Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown ( Rhee et al., 2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by...

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Veröffentlicht in:	Developmental cell 2006-06, Vol.10 (6), p.687-688
1. Verfasser:	Korswagen, Hendrik C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals beta Catenin - antagonists & inhibitors Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured Cercopithecus aethiops COS Cells Dishevelled Proteins Fundamental and applied biological sciences. Psychology Hydrogen Peroxide - pharmacology Mice Molecular and cellular biology NIH 3T3 Cells Nuclear Proteins - metabolism Oxidation-Reduction Oxidoreductases - metabolism Phosphoproteins - metabolism Phosphorylation Protein Binding Signal Transduction Thioredoxins - metabolism Wnt Proteins - antagonists & inhibitors Xenopus
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Beschreibung
Zusammenfassung:	Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown ( Rhee et al., 2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/β-catenin pathway. This work provides interesting new insight into cross-talk between redox and Wnt/β-catenin signaling in normal physiology and cancer.
ISSN:	1534-5807 1878-1551
DOI:	10.1016/j.devcel.2006.05.007