Structure–activity studies of oxazolidinone analogs as RNA-binding agents

Several oxazolidinone analogs were prepared and examined for binding to two structurally related T box antiterminator model RNAs, AM1A, and AM1A(C11U). We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.