Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns

The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride has been carried out and compared to that of the saturated external beta-turn const...

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Veröffentlicht in:	Organic & biomolecular chemistry 2005-06, Vol.3 (12), p.2287-2295
Hauptverfasser:	Duggan, Heather M E, Hitchcock, Peter B, Young, Douglas W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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