Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns

Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns

The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride has been carried out and compared to that of the saturated external beta-turn const...

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Veröffentlicht in:Organic & biomolecular chemistry 2005-06, Vol.3 (12), p.2287-2295
Hauptverfasser: Duggan, Heather M E, Hitchcock, Peter B, Young, Douglas W
Format: Artikel
Sprache:eng
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Zusammenfassung:The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride has been carried out and compared to that of the saturated external beta-turn constraint 18.
ISSN:1477-0520
1477-0539
DOI:10.1039/b503014e